Curing Diseases with Dietary Supplements: Part 2: Additional Reports and Mechanisms from the Cochran Medical Foundation

Whole Foods magazine

April 1998

Curing Diseases with Dietary Supplements: Part 2: Additional Reports and Mechanisms from the Cochran Medical Foundation

By Richard A. Passwater, Ph.D.

Last month we reviewed the impressive data from the first heart patient clinical trial of the Cochran Foundation of Medical Research (CFMR).

In the first six months of this clinical trial, the patients improved from an average New York Heart Association (NYHA) level of 3.1 to an average of 1.3. This was accompanied by dramatic improvements in cardiovascular function! On average, patients' blood pressures dropped from 153.7/113 to 101.5/69.6, and their pulse rates dropped from 104 to 76. Concomitant with these amazing improvements in cardiovascular function, their blood chemistries also improved significantly. Average total blood cholesterol levels dropped 39.6 mg/dl; LDL cholesterol (the "bad" cholesterol) levels dropped 48.3 mg/dl; HDL-cholesterol (the "good" cholesterol) increased by 14.5 mg/dl; HDL/LDL ratios improved by 216%; and triglycerides dropped 29.3 mg/dl. Prior to beginning the Cochran Regimen, medications could not bring about meaningful improvements. In fact, according to the physicians who have reviewed these preliminary results, no combinations of medications had ever brought about such dramatic improvements.

CFMR also is conducting several other clinical trials at this time, including a larger closed study of heart disease patients and initial clinical trials on Parkinson's disease, Huntington disease, autoimmune diseases (including rheumatoid arthritis, lupus, fibromyalgia syndrome and chronic fatigue syndrome), dystrophy diseases and other age-related diseases.

The Cochran Regimen to fight these diseases involves super nutritional amounts of nutrients and "mega" amounts of several hormones. The goal of the hormone revolution that started in 1994 and has been led by medical researchers such as Dr. William Regelson is to restore the levels of several "Super Hormones" to those of healthy 20-25 year olds. As we gain experience, it appears that this may be a fine goal for healthy persons, but seriously ill persons may need more than this. This is taken into account in the Cochran Regimen. Shortly, the developer of the Cochran Regimen, Tim Cochran, a theorist and therapeutic biochemist, will discuss with us the basis for his therapies; but first, let's chat with him some more about the results of his approach.


Passwater: I have had more than 20 physicians examine the data from the open heart-cardiovascular trial and they all say the results are phenomenal. What did the trial coordinator, Dr. Pravin Kini, say when he saw the results?

Cochran: It has indeed been interesting to witness the medical doctors' reactions as the various patients recover-not just from death's doorstep but, figuratively speaking, from inside the jaws of death as the Grim Reaper was already putting his teeth into them. The reactions have been very similar from the American physicians to the Indian physicians.

But, I will tell you how Dr. Kini reacted to one patient, the 86year-old listed in the charts (see table 2 in Part 1, March WHOLE FOODS, Page 104). Dr. Kini called me and was unbelievably excited about the fact that the man was walking. I said "So what?" Dr. Kini said, "You don't understand. This man has not walked in over two years. He had severe swelling of the feet for the past six-to-eight years. This man was bedridden. He is 86 years old and had to be carried from his bed to the toilet. He had to be hand-fed. He could not move without becoming breathless. After three weeks of being on the Cochran Regimen, he is walking and feeding himself. When the report came in from his personal doctor, I couldn't believe it. Even his doctor became very emotional. He was in a state of unbelievable happiness, beside himself, but in a positive, shocked way. I had to see for myself, so I drove a couple of hours to the patient's home. I saw with my own eyes his great improvement. His family and doctor were there.

"I can say only this," Dr. Kini continued. "I have been in medicine all my life. My father also is a physician, so I was raised in a medical family. I have never seen a real `miracle' until I saw this man rise from his death bed and totally regain his health. I'm still very emotionally shaken by what I have seen-a real `documented medical miracle.' My brain kept telling me that this is just impossible, but my eyes kept showing me just the opposite."

Passwater: That's a dramatic initial reaction. How about a longer term reaction by the Stanford cardiologists?

Cochran: One "pilot" patient, Dick M., was recently examined by the Stanford cardiologists and I have just received their report this morning. His pulse was 65 and his blood pressure was 121/62. His total blood cholesterol was 153, compared to 338 one and one-half years ago. His LDL-cholesterol (the "bad" cholesterol) is below normal and his HDL-cholesterol (the "good" cholesterol) has risen from the teens to the high 50s. His triglycerides also have dropped below normal.

The patient told me that the cardiologists said that they don't understand what is happening because they have never seen anything like this before. They told him, AYou have the blood of a 20 year old! You have better than textbook perfect blood. You are turning 61 in March, and we know of no one who 61 and who was NYHA level four a year ago and who is cured of cardiovascular disease now (NYHA=0). We don't believe that you will find another 61 year old in America who has these blood chemistries. We don't even know of anything close to this, where the blood chemistries were changed so will and health has been restored. It is totally unbelievable and truly remarkable.@

Passwater: Heart disease is one thing, but basically it is a simple matter of plumbing. Keeping the pipes clear and the pump pumping effectively. Others have made progress against heart disease, although not as impressive as your results so far.

However, Parkinson's disease and other neurological diseases are something else. They involve very complicated biochemistry that has resisted effective treatment. Dr. George Birkmayer has had some good results, but there is considerable room for more progress. CFMR has a Parkinson's disease clinical trial that is under way. Can you tell us about some of your pilot patients?

Cochran: Let me tell you about our first Parkinson's disease patient treated with the Cochran Regimen by Dr. Uday B. Muthane, assistant professor of neurology, National Institute of Mental Health and Neuro Sciences, in Bangalore, India. The patient was a 60-year-old doctor of pharmacology and was confirmed as having early stages of Parkinson's disease. The patient was videotaped before and during his treatments, which are ongoing. The results were immediate and profound. Within 24 hours, symptoms diminished, and within 48 to 72 hours of treatment with the Cochran Regimen for Parkinson's disease, he no longer had any symptoms.

However, Parkinson's disease patients must maintain the regimen indefinitely. Early in the treatment, this patient, who had been physically run down and had a poor immune response which was not yet corrected by the regimen, came down with the flu. 1>r. Muthane disc discontinued the regimen during the flu, acid within 24 to ,36 hours, the Parkinson's disease symptoms returned. Upon returning to the Cochran Regimen, the Parkinson's disease went into total remission within 48 hours. This pilot patient was taken off all of his Parkinson's disease medication lot- oil(, month before he started oil our protocol.

All signs of tremors arc gone and the patient call move about freely. At first, his movements produced sonic stiffness but since he hadn't moved much in the last year, this is not too surprising. He feels and acts normal. Each week his health continues to improve and he says he feels great. He is once again active and enjoying a normal life.

Dr. Muthane is quite a respected expert in Parkinson's disease and has trained in India and at Columbia-Presbyterian Medical Center in New York City. He has received several honors and awards based on his publications and presentations on Parkinson's disease. When he showed the results to other specialists, they were kind of shocked and almost in a state of disbelief after witnessing the videotape and medical records. We are hoping to be able to present results from our full clinical trial at a major conference on Parkinson's disease in December.

Word of mouth has gotten around and there are many Parkinson's disease patients asking to become part of the clinical trials. We have added as many as we can to our ongoing clinical trials.

Passwater: What other studies do you have under way?

Cochran: We have been doing pilot studies on lupus and fibromyalgia syndrome, chronic fatigue syndrome and also rheumatoid arthritis, all of which are showing very promising results. Patients are doing anywhere from 75% to 90%, better than what they were doing previously. Our lupus patients lave been able to get rid of their anti-inflammatory and pain pills essentially. With regard to fibromyalgia and chronic fatigue, we lave been able to make some radical improvements in which essentially we are regenerating or restimulating mitochondria production, but also giving enough hormones so that the body quits attacking itself. We have had some very good successes in early stages of those diseases. Now we will be going into larger pilot studies with larger groups. After that will come Ablinded@ or Aclosed@ studies.

Passwater: How about a report from your arthritis patients.

Cochran: OK. One 56-year old woman patient, Sue W., had moderate arthritis. She had to carry her left elbow around with her right hand because the pain was so great. She has had arthritis for about 15 years. It started in her lower spine, then moved to her hands and then on to her elbows and neck. Within 48 to 72 hours of the appropriate Cochran Regimen, the pain was reduced and the swelling in her elbow started to disappear. After four weeks on the regimen, the swelling in her elbow is completely gone, the pain is gone and she has total movement. In the same time, her hands were about 70% improved.

Recently, she was able to tie ribbons for gifts for six hours straight for a family wedding. There was no swelling or pain in her elbows or the joints in her hands. She said that it was totally miraculous. She estimated that before starting the regimen, she would have lasted no more than 20 minutes at this task. Her pain would have been too great and her joints just too tight to move. Now she has been taken back to a very early stage of the disease. She is about where she was between 8 and 10 years ago. She is not totally cured, but she is functioning much better than before. Her overall health has also greatly improved.

Passwater: That's gratifying. Let's now talk about the regimen itself. The quantities of nutrients and hormones that you use often involve high-range "supernutritional" levels for some, but even prescription levels for others. I am particularly pleased with your selenium levels as well as the other antioxidants. Bringing enough firepower to bear is important. I have seen too many reports where scientists have claimed that a natural compound didn't work when they didn't use enough to have an effect. Adding five IU of vitamin E or five micrograms (mcg) of selenium will not make a detectable difference in heart disease or cancer risk in a group of 1,000 people, but a hundred times those amounts will make for significant risk-reduction.

Cochran: Yes. One of my major concerns is that some people will think that if one amount is good, then three times that amount will be better. Not so! '1 he Cochran regimen dosage levels are designed for ill people. The dosages are already the highest aggressive levels drat optimize the individual's body chemistry to fight a particular disease. These ratios of minerals, hormones, amino acids and enzymes have to be kept in balance.

Passwater: You often use the terms "fight" or "fought." Your approach Seems to be total war against disease-lake no prisoners.

Cochran: Disease has been waging a war of attrition against the hotly for decades and is finally winning the war in the persons that CFMR is asked to treat. The attrition is slow at first but gains momentum over the years. It's much like a rock rolling down a hill. You can't hope to win by going about it piecemeal. Your body doesn't have decades left to fight a slow war against the disease.

Adding some nutrients is like throwing some small rocks and sand in front of this boulder that is racing downhill like an express train. Even restoring your blood levels to those of your prime years will not totally do the job. It's not enough to just stop the rock (the disease process); you also need to push the patient's biochemical and physiological function back up the hill to repair the damage that has already been done (restore normal health).

Returning the patients' blood chemistries to the levels they had at 2Q25 years of age is very important, but the patients' cells may still be 55, 65 or 75 years old and they have not been exposed to these levels and sets of cellular instructions and resources for 30 to 50 years. The levels of these hormones that were present when the person was a young adult are important once the disease is defeated. However, the amounts of nutrients and hormones used in my regimen are intended to provide sufficient cellular energy and instructions to overcome the disease processes, The normal "young adult" levels do not produce enough cellular power to push the patients' biochemical functions back up the hill, so to speak-to reverse the disease process.

We must overwhelm the disease Blitzkrieg it. Use all of our resources and attack from many different angles. In war, we use the Navy, Army and Air Force and all of them, not just a platoon or two and we attack from many angles In the war against disease, we need to use hormones and chemical messengers to tell our cells what to do and then give them the vitamins, minerals, amino acids, enzymes, coenzymes and essential fatty acids so that the cells can perform accordingly as they are now instructed to do.

We attack the disease from every biochemical pathway we can, 24 hours a day, non stop. We provide a very hostile environment for the disease to try to survive in . The regimen makes biochemical cracks in the disease's biochemical pathways. We make a major was on a molecular basis in the cellular trenches. As Stonewall Jackson said after Bull Run, where his troops routed a Union army many times their size, A A small force can whip a big force once the big force breaks ranks.@ In the was we are fighting, either the patient wins of the disease wins. If the patient wins, so does his family.

Passwater: What types of considerations do you take into account when you calculate the dosages needed?

Cochran: One factor is the amount of deterioration that has occurred in the patient. There is a deterioration of approximately 2.5% per annum. The hormonal production is dropping and so is the nutrient absorbency. If the patient is ingesting toxins, that can contribute to the rate of decline. The amounts of amino acids and enzymes that can be transported across the wall into the blood system decreases. As that happens, the rate of deterioration escalates even faster.

That's why you can look at one person who is 50 years old and who has never smoked or drank, never used "socially accepted" toxins and has lived a decent, sort of clean life, compare him or her with another person who has been smoking and drinking really hard since the age of 15, and you can see a radical deterioration in body tissue. It escalates. We factor these changes, on an individual basis, into the formulas used in determining the patients' natural compounds and their dosages.

At first, I could only theorize and make biochemical estimates on how much of an effect my formulas and regimen would have on NYHA level four (near death) cardiovascular disease patients. It was not a shot in the dark, but it was venturing into unexplored and undocumented territory. Now we have data that shows what the effects are.

Passwater: You have created new concepts about what should be done to improve someone's health-particularly when they are suffering from the diseases we have been discussing. What did you see that others missed? There is no documentation of anyone else doing what you are doing.

Cochran: Maybe I asked a different question. You can't get the right answers if you don't ask the right questions. Instead of asking, "What is there that is causing cardiovascular disease?" I asked, "What is not there now at, say, 62 years of age that is causing cardiovascular disease?" What was there when the person was between 18 and 25? He or she didn't have cardiovascular disease then? We started studying, those biochemical levels of what was going on in that body at its prime versus what is going on in that body now.

There is a radical drop in some hormonal levels between 25 and 65 years of age. I studied which hormones are dropping, Which ones are staying stable, which ones have an effect, which ones don't have an effect.

Then I studied which glands are functioning. If these glands aren't functioning any longer, what do we do to get them to function. If we can't get them to function, what can we do to stimulate function? We have been able to show that by getting certain amino acids to a certain level, we can induce the, pituitary gland to actually start producing and excreting the growth hormones that made your body what it was between the ages of 12 and 25. The exact same ones that your body totally understands. They are not made from some animal or other source.

We are not talking about growing in height again, but the growth hormones do cause tissues to regenerate quickly and immunological response to be greatly enhanced. Everyone freaks out about growth hormones, but basically your body needs growth hormones even when you reach physical maturity and you aren't growing anymore. Growth hormones are still being produced in small quantities when you are between 22 and 25 years old. They are being excreted throughout the day in small amounts and they help stabilize the body.

The other thing that I also looked at was this: "What is the greatest driving force in your body? What is it that is really immortal?" The only thing that is immortal is your DNA, genes and chromosomes. Your DNA, your genes have been coming down through the ages and they are still living and alive in you in one form or another. Remember that 5% of the information stored in your genes is what made you. The other 95% is just sitting there, locked away so to speak and not active.

When I look at a body, I see biochemical and biophysical processes requiring a massive amount of organized, correctly applied energy to move an individual from a mother's womb to 12 years of age. Think of the hard work it took to get you to that point. By the time you dart reaching puberty, start moving into adolescence, You experience a flood of hormones that will never r hr duplicated again. In most people, this deluge of horn hormones subsides between the ages of 20 and 2'?. Why this massive push here? It's because nature has to got you physically prepared for transfer of DNA. How do you do that? The answer is by procreating :mot producing offspring. It's a genetic thing. This hurricane of hormones hits ill the teens and early 20s, tends to plateau between 22 and 25 and then just drops and keeps on dropping because, basically, Yom are only around to make sure your children make it to an age where they can procreate and have children and pass on the gene pool.

The majority of people accept this pattern. They see it its the natural order of life; it has always been this way. 1, however, have always thought that if you can control the molecular operation that got you to 2225 years old, then you can control Cellular genesis. That is, control DNA.

What do we do to regulate the DNA? How do we get into the nucleus? The nucleus has all kinds of portals but you have to get the right component inside the cellular fluid through the processor walls into this cell to get it to start stimulating the DNA to regulate it. Here is the one basic thing everybody seems to miss. All genes, all cells obey laws of physics and chemistry. They obey them in getting your body to 25 and then there is a contraction. There is a shutting down. So by manipulating the DNA, by manipulating what was there previously, you are giving the instructions in the language for those tissues to regenerate accordingly. The cells repair themselves and get on with their job of passing on perfect DNA, because that is where the actual immortality of life is, the continual passing on and the manipulation of that gene pool going forward. We are just a link in that chain. We are just a carrier.

What we are accomplishing is to manipulate that regulation and duplicate what it once was. I had a doctor once say to me, "You are really big on hormones and amino acids and enzymes."

I said, "Mat's the only language that cells understand."

He said, "Hormones aren't going to do that much."

I said, "OK, take a 10-year-old boy and a 10-year old girl out to a track field and have them do 20 back-to-back 100yard wind sprints and the odds are that she is going to beat him about as many times as he beats her. This is before she starts ovulating; this is before he starts sperm production. I said, "Now let's come back and put them to the same test at age 18 or 20." I said, "the odds are that he is going to beat her, and he is going to beat her consistently. Her body has changed radically; his body has changed radically. What did that, what was the effect that caused that to happen?"

He looked at me sort of blankly.

I said, "hormones." Hormones did all that; hormones changed those bodies and made them what they are today. Hormones stimulated his DNA to produce all that large muscle mass, helped him to become top-heavy, made his voice drop and stimulated body hair growth. In her case, hormones associated with the onset of ovulation made her more bottom-heavy

and gave her an hour-glass shape. Hormones, enzymes and amino acids were the triggers for all this activity. These are very, very powerful substances. All of the world's medical knowledge can not come close to snatching the power of hormones.

Passwater: You mentioned cell communication cells talking to each other chemically. You mentioned biophysics. Be a bit more specific about biophysics. What are you talking about here as opposed to feeding the cells with just biochemical?

Cochran: We have been able to determine the rates of decline and translate them into mathematical equations for each of the various natural compounds. These equations consider the biophysics and biochemistry on not only what is happening now, and at what rate, but what the causes are and what has to be done just to stop the tissue deterioration. Then you have to give the cellular language commands, starting at the molecular level and supplying the biochemical resources to not only stop the deterioration, but to give it the energy to reverse it. That's where a combination of biophysics and biochemistry comes in because basically this is all happening on a molecular level. The lack of the biochemical instructions is causing the system to break down. This is where the war against your body is happening. This is where the trenches are, and this is where the destruction is going on.

Passwater: What happens if you "feed" the cell what it needs without supplying the instructions?

Cochran: There are a lot of people out there running around preaching about one nutrient or another. The patient may be able to absorb some of these nutrients, but the individual cells won't be able to get to their maximum capacity and capability because their mitochondria aren't working properly at that age or in that disease state, and their nuclei aren't getting the messages telling them what to do. It does no good to give a cell overwhelming amounts of nutrients when you are not giving the cell the proper direction from the amounts of hormones necessary to stimulate them to use those nutrients. Hormones are very important. 'They are biochemical substances which are specially produced by the body, and when they are secreted into the bloodstream, they exercise physiological control over the cells.

Passwater: What happens if you give the cells their "instructions," but don't fully nourish them?

Cochran: If you don’t have the raw materials and proper blueprints to build your body, it can’t be done. If you were doing maintenance work on your home and a foreman and his crew showed up to do the work, but no materials had been ordered, would anything get fixed? If you put in the correct amount of needed materials along with the needed hormones which have direct effect on the utilization of those resources inside the cell, you get the job done. If they are not there – together – then the cells have a harder time utilizing those nutritional resources because they are not being stimulated to do so.

Passwater: You are implying from what you have said so far that health can be regained in terms of cardiovascular health without drugs, without vigorous exercise or without stress reduction.

Cochran: It is very hard to tell somebody who is a cardiovascular level three or four to go out and start walking when he or she has a hard enough time just getting out of bed. Forcing this individual out of bed to exercise before physiological regeneration is well under way might kill him or her. Physical activity can increase, but only as the patient's condition improves. Remember, we are dealing with some gravely ill people here.

Let's look at conventional medicines for a moment. Most of these drugs are designed to help stabilize a bad situation, but most patients are still sliding down a biological "greased pole" towards their deaths. The conditions that cause the disease must be reversed, not just slowed. There was a lot of concern initially by the cardiologists who placed pilot patients on the Cochran Regimen. They didn't trust the idea that hormones, amino acids, coenzymes, enzymes, minerals, vitamins and essential fatty acids would make a difference. These physicians had not seen their patients biochemically improve to a better state of health during the 10 years or so that they had been treating them. I had theorized what could happen when the patients are given the dosages of natural compounds that I had calculated would be needed. These were therapeutic dosages that had never been used before. I explained to the doctors that they had the patient for 10 years and had indeed kept him alive till now, but he was slipping towards death. I told them that they had done everything that they had known to do and now it was time to try something new. We didn't know what the effect would be, but I had confidence from my understanding of biochemistry that it would work and that the response would be immediate. mediate.

If we didn't reverse the cause, we would be fighting a war of attrition which we would be sure to lose. For example, a patient in San Jose was on all the beta blockers, all the hypertension you can shake a stick at and had been on them for 10 year's. There were some very big fears about putting him on this sort of hormonal, amino acid, enzyme and mineral routine-especially at dosages we thought would be needed for a therapeutic effect.

But he started showing signs of improvement within 24 to 48 hours after he started on the regimen.

Passwater: I find it interesting and reassuring that you videotape your patients both before and after treatment.

Cochran: We are videotaping the patients with their doctors before and during treatment in order to show improvements as they occur. The videotapes, along with clinical details, information on when the patient started the regimen and how rapidly the patient progressed, permits verification and witnessing. It is rather spectacular.

Dr. Regelson told me you just don't go around moving people from level four to level one; it just doesn't happen. He says that now there is this base of patients where we have been able to do it. This is one of the reasons why we contacted you and Dr. Regelson more recently. I wanted you two to know that you have been correct all along regarding the two areas in which you specialize. We are using much of your information and are able to move further on. Of course, I have been using higher, more therapeutic dosages and complex formulations as you have seen, getting some rather remarkable results. I wanted you to know that our medical trials were verifying your life long work.

Passwater: 1 appreciated that. I have had my antioxidant synergism, aging, heart and cancer research verified and I had earlier verification of my "Supernutrition Principle" from Canadian researchers in 1976, and many hundreds of "Thank You' or "God Bless You" letters telling me that my research or books saved lives. And I get a lot of hugs at my lectures, but I have never lead formal clinical trials as verification.

We are chatting informally here prior to your being able to formalize these studies for publications in medical journals. When do you plan on publishing these results where other scientists and physicians can evaluate them?

Cochran: A soon as our data from the clinical trials reach the nine-month point, we will begin writing them up for submission to peer-reviewed journals.

Passwater: Are you satisfied with your results so far?

Cochran: It's exciting when someone who is supposed to be dead calls up and thanks you for saving his life. Or when a wife or child calls up and says, "Thank you for saving my husband's (or father's) life." It makes it all worthwhile because all these theories and ideas that have been popping around in my head for a very long period of time have now blossomed and become reality. That is one of the reasons why I called you approximately a year ago.

Passwater: Can physicians contact you to become involved with your research program or with your treatment program?

Cochran: Physicians can join the Cochran Medical Association (CMA). CMA is part of the CFMR. We are always looking for more doctors who would be interested in becoming members of the association. They are then trained , assisted and supported by CMA using these therapies on their patients.

Passwater: How about patients? How does one contact CFMR if one is seeking treatment?

Cochran: We do not treat patients here, but work with patients through their personal physicians. Patients or physicians may request information forms which are to be filled out by the physician and returned to CFMR for our calculation of the appropriate regimen.

Remember, one size doesn't fit all. It's not just a matter of weight and age, but a combination of many factors. Some of the natural substances that are effective against arthritis are contraindicated in heart disease, and vice versa. The overall health has to be taken into consideration. We ran be reached by e-mail at Cochran Information forms can be obtained from our Web site at or by faxing (909) 338-4010.

Passwater: Thank You lot sharing your clinical research results with us. We

eagerly await the formal publication of your findings. WF

Cochran: If you don't have the raw materials and proper blueprints to build your body, it can't be done. If you were doing maintenance work on your home and a foreman and his crew showed up to do the work, but no materials had been ordered, would anything get fixed? If you put in the correct amount of needed materials along with the needed hormones which have direct effect on the utilization of those resources inside the cell, you get the job done. If they are not there-

together-then the cells have a harder time utilizing those nutritional resources because they are not being stimulated to do so.

1998 Whole Foods Magazine and Richard A. Passwater, Ph.D.

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